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IL-6 (human), (recombinant)

 
ALX-201-818-0020 20 µg 221.00 USD
 
ALX-201-818-0100 100 µg 803.00 USD
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  • Carrier-free

Product Specification

Alternative Name:Interleukin-6, IFN-β2, B-cell differentiation factor, BSF-2, HSF, MGI-2
 
MW:~21kDa
 
Source:Produced in E. coli. Non-glycosylated protein, containing 184 amino acids.
 
UniProt ID:P05231
 
Formulation:Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10mM sodium phosphate, pH 7.5.
 
Purity:≥95% (Reducing and Non-reducing SDS-PAGE)
 
Endotoxin Content:≤1 EU/μg protein measured by kinetic LAL analysis.
 
Appearance:White lyophilized (freeze-dried) powder.
 
Biological Activity:B9 Cell Proliferation ED50 ≤25 pg/mL (≥4.0 x 10^7 units/mg)
 
Reconstitution:Sterile water at 0.1 mg/mL
 
Shipping:Ambient
 
Long Term Storage:-80°C
 
Use/Stability:Add 0.1% BSA for long term storage.
 
Handling:Store at -80°C after reconstitution
 
Scientific Background:Interleukin 6 (IL-6) is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Rα and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells.
 
Regulatory Status:RUO - Research Use Only
 
IL-6  (human), (recombinant) SDS-PAGE
Figure 1: 1µg in each lane (-) non-reducing conditions and (+) reducing conditions in a 4-20% TRIS-Glycine gel, stained with Coomassie Blue. Human IL-6 has a predicted MW of 20.9 kDa.
IL-6  (human), (recombinant) image
Figure 2: B9 cells were cultured with dilutions of Human IL-6. Cell proliferation can be measured and the linear portion of the curve can be used to calculate the ED50.
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IL-6  (human), (recombinant) SDS-PAGE IL-6  (human), (recombinant) image

Product Literature References

TLR5 activation by flagellin induces doxorubicin resistance via interleukin-6 (IL-6) expression in two multiple myeloma cells: H.Y. Cho, et al.; Cell. Immunol. 289, 27 (2014), Abstract;

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