Alternative Name: | Transforming growth factor β3 |
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MW: | ~25.5kDa |
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Source: | Produced in E. coli. Non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains. |
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UniProt ID: | P17125 |
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Concentration: | 0.25mg/ml |
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Formulation: | Liquid. In 20% ethanol and 0.12% acetic acid. |
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Purity: | ≥98% (Reducing and Non-reducing SDS-PAGE) |
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Endotoxin Content: | ≤1 EU/μg protein measured by kinetic LAL analysis. |
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Appearance: | Clear solution. |
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Biological Activity: | The activity is determined by the cell toxicity assay, using the WHO Standard 98/608 as a direct comparison, which is typically observed at concentations <0.05ng/ml. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | +4°C |
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Use/Stability: | Stable at +4°C for 1 year from date of purchase. |
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Scientific Background: | The transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in a variety of cells. Recent data suggests that individual TGF-β isoforms (TGF-β1, -β2 and –β3) have overlapping, yet distinct biological actions and target cell specificities, both in developing and adult tissues. TGF-β3 is a new isoform that is presumed to play an important role in wound repair and scarring. TGF-β3 is also thought to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. |
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Regulatory Status: | RUO - Research Use Only |
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