| Alternative Name: | CCL17, Thymus and activation regulated chemokine, ABCD-2, SCYA17 |
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| MW: | ~8.1kDa |
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| Source: | Produced in E. coli. Non-glycosylated protein, containing 71 amino acids. |
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| UniProt ID: | Q92583 |
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| Formulation: | Lyophilized from 0.02% TFA. Sterile filtered. |
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| Purity: | ≥98% (HPLC, Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm) |
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| Endotoxin Content: | ≤1 EU/μg protein measured by kinetic LAL analysis. |
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| Appearance: | White lyophilized (freeze-dried) powder. |
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| Biological Activity: | The activity is determined by the ability to chemoattract human T cells which is typically observed at a concentration of 2-40ng/ml. |
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| Reconstitution: | When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage. |
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| Handling: | Centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20°C. |
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| Scientific Background: | Thymus and activation regulated chemokine (TARC), also known as CCL17, is a chemokine produced by thymus tissue constitutively and activated PBMCs (mainly DCs). TARC signals through the CCR4 receptor to induce chemotaxis of Th2 cells. TARC is thought to be important in asthma and allergic diseases, along with bacterial and viral infections. |
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| Regulatory Status: | RUO - Research Use Only |
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