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Clusterin (secretory form) (human), (recombinant) (His-tag)

ALX-201-761-0010 10 µg 230.00 USD
ALX-201-761-0050 50 µg 531.00 USD
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Product Details

Alternative Name:TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
Source:Human cells
UniProt ID:P10909
Formulation:Lyophilized. From a 0.2 μM filtered solution of PBS, pH 7.4.
Purity:≥90% (reducing SDS-PAGE)
Endotoxin Content:< 0.1ng/µg (1 IEU/µg).
Reconstitution:Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Working aliquots are stable for up to 3 months when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Scientific Background:Clusterin is a secretory heterodimeric disulfied-linked glycoprotein containing 449 amino acids that is expressed in virtually all tissues, and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. In addition, clusterin is up/ down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
Regulatory Status:RUO - Research Use Only

General Literature References

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.: J.C. Lambert, et al.; Nat. Genet. 41, 1094 (2009), Abstract;

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