Product Details
| Alternative Name: | Complement C1q tumor necrosis factor-related protein 5, C1qTNF5 |
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| Source: | Produced in E. coli. The mature peptide of human CTRP5 (aa 16-243) is fused at the N-terminus to a His-tag. |
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| UniProt ID: | Q9BXJ0 |
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| Formulation: | Lyophilized from a 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Endotoxin Content: | <1.0EU/µg purified protein (LAL test) |
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| Reconstitution: | Reconstitute in an appropriate buffer. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Working aliquots are stable for up to 3 months when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Scientific Background: | CTRP5 is a member of the CTRP familly designated as C1q tumor necrosis factor-related proteins. The CTRPs are paralogs of the adiponectin protein characterized by an N-termius variable region and C-terminal globular domain (C1q). CTRP5 is a putative secreted protein. A mutation in CTRP5 gene has been genetically linked to the Late-onset retinal degeneration (L-ORD) disease wich lead to severe visual loss. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1: SDS-PAGE of CTRP5 (human) (rec.) (His) (Prod. No. ALX-201-451).
Figure 2: CTRP5 (human) (rec.) (His) (Prod. No. ALX-201-451) activates AMPK signaling pathway in rat L6 myoblasts. Method: Differentiated rat L6 myoblasts were stimulated with control buffer or 0.5ug/ml CTRP5 (human) (rec.) (His) for 30min. The cell lysate was subjected to immunoblotting with antibodies against pAMPK and total AMPK.
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General Literature References
A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS
101, 10302 (2004),
Abstract;
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration: C. Hayward, et al.; Hum. Mol. Genet.
12, 2657 (2003),
Abstract;
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