| Alternative Name: | Angiopoietin-like protein 7, Cornea-derived transcript 6 protein |
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| Source: | Produced in HEK 293 cells. Fibrinogen-like domain of human ANGPTL7 (angiopoietin-like protein 7) (aa 126-346) is fused at the N-terminus to a FLAG®-tag. |
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| UniProt ID: | O43827 |
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| Concentration: | ~0.5mg/ml |
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| Formulation: | Liquid. 0.2µm-filtered solution in PBS. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg protein (LAL-test). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Working aliquots are stable for up to 3 months when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Scientific Background: | Human ANGPTL7 is produced as a secreted glycoprotein. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1. Human ANGPTL7, characterized as potent target gene of wnt/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine. |
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| Technical Info/Product Notes: | FLAG is a registered trademark of Sigma-Aldrich Co. |
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| Regulatory Status: | RUO - Research Use Only |
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