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Saposin C (human), (recombinant)

An essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease.
ALX-201-262-C050 50 µg 472.00 USD
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Glycoprotein with a variety of functions. Important for exchange of lipids from CD1 molecules to lysosomal antigens.

Product Details

Alternative Name:Co-β-glucosidase, A1 activator, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2
Source:Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag.
UniProt ID:P07602
Formulation:Lyophilized. In 50mM Tris, pH 6.0, containing 150mM sodium chloride.
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution:Reconstitute with 100µl sterile water.
Shipping:Blue Ice
Long Term Storage:+4°C
Use/Stability:Stable for at least one year after receipt when stored at +4°C.
Regulatory Status:RUO - Research Use Only
Saposin C (human), (recombinant) SDS-PAGE
SDS-PAGE Analysis: Lane 1: MWM; Lane 2: 1.0 µg of purified Saposin C.
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Saposin C (human), (recombinant) SDS-PAGE

Product Literature References

Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins: D. Zhou, et al.; Science 303, 523 (2004), Abstract;
Saposin C is required for lipid presentation by human CD1b: F. Winau, et al.; Nat. Immunol. 5, 169 (2004), Abstract;

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