Product Details
| Alternative Name: | Leukocyte-associated Ig-like receptor 1, CD305 |
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| MW: | ~11.7kDa. |
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| Source: | Produced in E. coli. Extracellular domain of human LAIR-1 (aa 22-125). |
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| UniProt ID: | Q6GTX8 |
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| Concentration: | 1mg/ml |
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| Formulation: | Liquid. In 20mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride and 1mM EDTA. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Scientific Background: | LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. It features of a leader sequence, extracellular domain, transmembrane domain and a cytoplasmic region. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: 14% SDS-PAGE of human recombinant LAIR-1 (22-125) (Prod. No.
ALX-201-184)."
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General Literature References
Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells: J.G. Sathish, et al.; J. Immunol.
166, 1763 (2001),
Abstract;
Full Text
LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells: L. Meyaard; Curr. Top. Microbiol. Immunol.
244, 151 (1999),
Abstract;
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells: L. Meyaard, et al.; J. Immunol.
162, 5800 (1999),
Abstract;
Full Text
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes: L. Meyaard, et al.; Immunity
7, 283 (1997),
Abstract;
