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PARP-1 (human), (recombinant) (high purity)

ALX-201-063-C020 20 µg 602.00 USD
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Product Details

Alternative Name:Poly(ADP-ribose) polymerase 1
Source:Produced in Sf9 insect cells. Produced in a baculovirus expression system.
UniProt ID:P09874
Formulation:Liquid. In 100mM TRIS-HCl, pH 7.5, containing 14mM β-mercaptoethanol, 0.5mM EDTA, 0.5mM PMSF and 10% glycerol.
Purity:≥99% (SDS-PAGE)
Purity Detail:Affinity purified.
Specific Activity:≥600U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min. at 25°C, pH 7.5.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles.
Regulatory Status:RUO - Research Use Only
PARP-1 (human), (recombinant) (high purity) image
Quality Control: 10% SDS-Polyacrylamide gel.
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PARP-1 (human), (recombinant) (high purity) image

Product Literature References

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation: A. Tolić , et al.; Epigenetics Chromatin 15, 11 (2022), Abstract;
Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors: S. Di Micco, et al.; Bioorg. Med. Chem. 26, 3953 (2018), Abstract;
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1: L.C. Lehmann, et al.; Mol. Cell 68, 847 (2017), Abstract; Full Text
PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair: Y. Hu, et al.; Cancer Discov. 4, 1430 (2014), Abstract; Full Text
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation: G. Jankevicius, et al.; Nat. Struct. Mol. Biol. 20, 508 (2013), Abstract;
Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry: J.D. Chapman, et al.; J. Proteome Res. 12, 1868 (2013), Abstract;
Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription: T. Wu, et al.; Free Radic. Biol. Med. 67C, 69 (2013), Abstract;
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis: C. Leptrête, et al.; Int. J. Biochem. Cell Biol. 41, 1046 (2009), Abstract;
Poly(ADP-ribose) polymerase 1 binds to Pax8 and inhibits its transcriptional activity: T. Di Palma, et al.; J. Mol. Endocrinol. 41, 379 (2008), Abstract;
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem. 279, 5244 (2004), Abstract; Full Text
Overproduction and large-scale purification of the human poly(ADP- ribose) polymerase using a baculovirus expression system: H. Giner, et al.; Gene 114, 279 (1992), Abstract;

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