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Furin convertase (human), (recombinant)

ALX-201-002-U050 50 U 330.00 USD
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Product Details

Alternative Name:Furin, PACE, Paired basic amino acid residue cleaving enzyme
Source:Produced in Drosophila melanogaster Schneider 2 cells. Corresponds to aa 108-714 of the human preproenzyme. Does not contain the C-terminal and transmembrane domains. Produced by plasmid transfection expression.
UniProt ID:P09958
Quantity:~50U/vial. One unit is defined as the amount of enzyme that releases 1pmol AMC from Boc-Arg-Val-Arg-Arg-AMC (Prod. No. ALX-260-040) per minute.
Formulation:Liquid. In 100mM HEPES, pH 7.5, containing 25% glycerol, 150mM sodium chloride and 1mM calcium dichloride.
Purity:≥90% (one major band at ≥83kDa)
Biological Activity:Cleaves precursor proteins C-terminal to an Arg-X-X-Arg motif.
Specific Activity:One unit cleaves 24pmol (2µg) of protective antigen or 100pmol (2.5µg) of human proendothelin-1 per hour at 30°C in 100mM HEPES, pH 7.6, containing 1mM calcium dichloride, 0.5% Triton X-100 and 1mM 2-mercaptoethanol.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Do not aliquot. Keep vial on ice during use and put immediately back in -80°C freezer.
Handling:Do not freeze/thaw.
Regulatory Status:RUO - Research Use Only

Product Literature References

Internally quenched fluorogenic substrate for furin: H. Angliker, et al.; Anal. Biochem. 224, 409 (1995), Abstract;
Processing of proendothelin-1 by human furin convertase: J.-B. Denault, et al.; FEBS Lett. 362, 276 (1995), Abstract;
Purification of recombinant soluble forms of furin produced in Chinese hamster ovary cells: K. Nakayama; Meth. Enzymol. 244, 167 (1994), Abstract;
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage: R. Leduc, et al.; J. Biol. Chem. 267, 14304 (1992), Abstract; Full Text
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen: S.S. Molloy, et al.; J. Biol. Chem. 267, 16396 (1992), Abstract; Full Text

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Furin convertase substrate (fluorogenic) 

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