Product Details
| MW: | ~52kDa (fully glycosylated homodimer) |
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| Source: | Human cytotoxic granules of NK-92 cells. |
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| EC: | 3.4.21.78 |
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| UniProt ID: | P12544 |
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| Formulation: | Liquid. In ~0.15M sodium chloride. |
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| Purity Detail: | Purified by differential solubilization and cation exchange chromatography. Dialyzed against 0.15M sodium chloride and concentrated. |
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| Specific Activity: | ~9.2U/µg protein. One unit is defined as the amount of enzyme that hydrolyzes 1nmole of Z-Lys-SBzl per min. at 25°C in 0.05M TRIS, pH 8.0, containing 0.15M NaCl, 0.01% Triton X-100, 0.3mM DTNB. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 6 months when stored at -80°C. Do not store dilute solutions (1-1000ng/ml) for more than 24 hours. |
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| Handling: | For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study: D.M. Leistner, et al.; Eur. Heart J.
41, 3549 (2020),
Abstract;
Full Text
Human and mouse granzyme a induce a proinflammatory cytokine response: S.S. Metkar, et al.; Immunitiy
29, 720 (2008),
Abstract;
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity
22, 355 (2005),
Abstract;
