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Granzyme B (human lymphocytes)

Highly active serine protease that triggers apoptosis
ALX-200-602-C010 10 µg Inquire for pricing
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Product Details

Source:Isolated from YT NK cell line using described methods. Active enzyme.
UniProt ID:P10144
Formulation:Liquid. In 150mM sodium chloride. Contains no preservatives.
Biological Activity:Using standard cell lines, 1µg/ml is sufficient to kill 1x106 cells when delivered by the appropiate agent.
Shipping:Dry Ice
Long Term Storage:-80°C
Use/Stability:Do not dilute below 1mg/ml. Dilute solutions should be used within 24 hours.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms: C.S. Backes, et al.; J. Biol. Chem. 293, 16348 (2018), Abstract; Full Text
Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers: L. Mezache, et al.; Mod. Pathol. 28, 1592 (2015), Abstract;
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis: C.J. Froelich, et al.; J. Biol. Chem. 271, 29073 (1996), Abstract; Full Text
Rapid purification of cationic granule proteases: application to human granzymes: W.L. Hanna, et al.; Protein Purif. Exp. 4, 398 (1993), Abstract;

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