Product Details
| MW: | ~32kDa. |
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| Source: | Isolated from YT NK cell line using described methods. Active enzyme. |
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| EC: | 3.4.21.79 |
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| UniProt ID: | P10144 |
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| Formulation: | Liquid. In 150mM sodium chloride. Contains no preservatives. |
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| Biological Activity: | Using standard cell lines, 1µg/ml is sufficient to kill 1x106 cells when delivered by the appropiate agent. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Do not dilute below 1mg/ml. Dilute solutions should be used within 24 hours. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms: C.S. Backes, et al.; J. Biol. Chem.
293, 16348 (2018),
Abstract;
Full Text
Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers: L. Mezache, et al.; Mod. Pathol.
28, 1592 (2015),
Abstract;
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis: C.J. Froelich, et al.; J. Biol. Chem.
271, 29073 (1996),
Abstract;
Full Text
Rapid purification of cationic granule proteases: application to human granzymes: W.L. Hanna, et al.; Protein Purif. Exp.
4, 398 (1993),
Abstract;
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