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Obestatin (mouse, rat)

Food intake modulator
ALX-164-005-M001 1 mg 211.00 USD
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Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.

Product Details

Peptide Content:≥80%
Purity:≥97% (HPLC)
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Obestatin inhibits dopamine release in rat hypothalamus: L. Brunetti, et al; Eur. J. Pharmacol. 641, 142 (2010), Abstract;
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment), Abstract;
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005), Abstract;

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