Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Details
| Sequence: | H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2 |
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| Formula: | C116H176N32O33 |
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| MW: | 2546.9 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | ≥80% |
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| Purity: | ≥97% (HPLC) |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science
310, 985 (2005), (Comment),
Abstract;
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science
310, 996 (2005),
Abstract;
