For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Details
| Alternative Name: | NEMO-binding domain peptide |
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| Sequence: | GRKKRRQRRR-GG-TALDWSWLQTE-amide |
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| Formula: | C121H202N48O32 |
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| MW: | 2841.2 |
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| Quantity: | 50µl |
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| Concentration: | 10mM |
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| Formulation: | Liquid. In sterile PBS. |
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| Purity: | ≥95% (HPLC) |
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| Shipping: | Dry Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Handling: | Keep on ice at all times. Protect from moisture. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque: A. Sakamoto, et al.; JCI Insight
8, e154922 (2023),
Abstract;
Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development: E.C. Dresselhaus, et al.; J. Neurosci.
38, 4093 (2018),
Abstract;
Full Text
CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury: H. Akahori, et al.; Nat. Commun.
6, 7792 (2015),
Application(s): Intraperitoneal administration in mice,
Abstract;
Disruption of IKK-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to HDAC inhibitors: Y. Dai, et al.; J. Biol. Chem.
286, 34036 (2011),
Abstract;
Improvement of cardiac contractile function by peptide-based inhibition of NF-kappaB in the utrophin/dystrophin-deficient murine model of muscular dystrophy: D.A. Delfin, et al.; J. Transl. Med.
9, 68 (2011),
Abstract;
Full Text
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo: E. Jimi, et al.; Nature Med.
10, 617 (2004),
Abstract;
Characterization of the Ikappa B-kinase NEMO binding domain: M.J. May, et al.; J. Biol. Chem.
277, 45992 (2002),
Abstract;
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M.J. May, et al.; Science
289, 1550 (2000),
Abstract;
