ORL1 receptor agonist. The ORL1 receptor structurally resembles opioid receptors and is negatively coupled with adenylyl cyclase.
Product Details
| Alternative Name: | Orphanin FQ |
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| Sequence: | H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH |
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| Formula: | C79H129N27O22 |
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| MW: | 1809.1 |
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| CAS: | 170713-75-4 |
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| Quantity: | *Sold as net peptide weight |
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| Purity: | ≥97% |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility: A.L.M. Salinas, et al.; Mol. Psychiatry
27, 2425 (2022),
Abstract;
Primary structure and tissue distribution of the orphanin FQ precursor: H.-P. Nothacker, et al.; PNAS
93, 8677 (1996),
Abstract;
Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide: Y. Shimohigashi, et al.; J. Biol. Chem.
271, 23642 (1996),
Abstract;
Full Text
Structure-activity relationship studies on the novel neuropeptide orphanin FQ: R.K. Reinscheid, et al.; J. Biol. Chem.
271, 14163 (1996),
Abstract;
Full Text
Isolation and structure of the endogenous agonist of opioid receptor- like ORL1 receptor: J.-C. Meunier, et al.; Nature
377, 532 (1995),
Abstract;
N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin: Y. Saito, et al.; BBRC
217, 539 (1995),
Abstract;
Orphanin FQ: a neuropeptide that activates an opioidlike G protein- coupled receptor: R.K. Reinscheid, et al.; Science
270, 792 (1995),
Abstract;
