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Ghrelin (rat)

Endogenous GHS-R ligand
ALX-157-022-M001 1 mg 425.00 USD
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Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.

Product Details

Purity:≥98% (HPLC)
Solubility:Soluble in H2O or 5% acetic acid.
Reconstitution:Reconstitute by adding 100 ul H2O to 1 mg of Ghrelin peptide.
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells: X. He, et al.; Neural Regen. Res. 17, 170 (2021), Abstract;
Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes: A. Magdaleno-Mendez, et al.; Endocrine 48, 929 (2015), Abstract;
Upregulation of voltage-gated calcium channel cav1.3 in bovine somatotropes treated with ghrelin: V.M. Salinas Zarate, et al.; J. Signal Transduct. 2013, 527253 (2013), Abstract; Full Text
Obestatin inhibits dopamine release in rat hypothalamus: L. Brunetti, et al; Eur. J. Pharmacol. 641, 142 (2010), Abstract;
Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect: C.X. Huang, et al.; Peptides 30, 2286 (2009), Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review), Abstract;
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review), Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review), Abstract;
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000), Abstract; Full Text
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999), Abstract;

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