Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system.
Product Details
| Sequence: | H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
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| Formula: | C149H249N47O42 |
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| MW: | 3370.9 |
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| CAS: | 258279-04-8 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥98% |
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| Solubility: | Soluble in distilled water or 5% acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells: X. He, et al.; Neural Regen. Res.
17, 170 (2021),
Abstract;
Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation: N. Sun, et al.; Brain Res. Bull.
124, 278 (2016),
Abstract;
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab.
16, 436 (2005), (Review),
Abstract;
Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol.
40, 900 (2005), (Review),
Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev.
85, 495 (2005), (Review),
Abstract;
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol.
142, 413 (2000),
Abstract;
Full Text
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature
402, 656 (1999),
Abstract;
