Replaces Prod. #: BML-CN220
Endogenous intestinal guanylyl cyclase activator.
Product Details
| Sequence: | H-Pro-Asn-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH(Disulfide bonds between Cys4-Cys12 and Cys7-Cys15). |
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| Formula: | C60H90N16O22S4 |
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| MW: | 1515.7 |
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| CAS: | 144940-98-7 |
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| Formulation: | Lyophilized |
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| Purity: | ≥99% |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Intestinal guanylate cyclase possesses an extracellular ligand binding domain, a transmembrane domain, an intracellular protein kinase-like region and a cyclase catalytic domain. GC-C is expressed in various mammalian tissues including intestine, adrenal gland, airway epithelial cells, brain, and olfactory and tracheal mucosa. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cloning and expression of guanylin. Its existence in various mammalian tissues: S. Schulz, et al.; J. Biol. Chem.
267, 16019 (1992),
Abstract;
Full Text
Guanylin: an endogenous activator of intestinal guanylate cyclase: M.G. Currie, et al.; PNAS
89, 947 (1992),
Abstract;
Human guanylin: cDNA isolation, structure, and activity: R.C. Wiegand, et al; FEBS Lett.
311, 150 (1992),
Abstract;
Rat guanylin cDNA characterization of the precursor of an endogenous activator of intestinal guanylate cyclase: R.C. Wiegand, et al.; BBRC
185, 812 (1992),
Abstract;
