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Guanylin (rat, mouse)

Guanylyl cyclase activator
 
ALX-157-011-MC01 0.1 mg 149.00 USD
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Replaces Prod. #: BML-CN220

Endogenous intestinal guanylyl cyclase activator.

Product Specification

Sequence:H-Pro-Asn-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH(Disulfide bonds between Cys4-Cys12 and Cys7-Cys15).
 
Formula:C60H90N16O22S4
 
MW:1515.7
 
CAS:144940-98-7
 
Formulation:Lyophilized
 
Purity:≥99%
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Scientific Background:Intestinal guanylate cyclase possesses an extracellular ligand binding domain, a transmembrane domain, an intracellular protein kinase-like region and a cyclase catalytic domain. GC-C is expressed in various mammalian tissues including intestine, adrenal gland, airway epithelial cells, brain, and olfactory and tracheal mucosa.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Cloning and expression of guanylin. Its existence in various mammalian tissues: S. Schulz, et al.; J. Biol. Chem. 267, 16019 (1992), Abstract; Full Text
Guanylin: an endogenous activator of intestinal guanylate cyclase: M.G. Currie, et al.; PNAS 89, 947 (1992), Abstract;
Human guanylin: cDNA isolation, structure, and activity: R.C. Wiegand, et al; FEBS Lett. 311, 150 (1992), Abstract;
Rat guanylin cDNA characterization of the precursor of an endogenous activator of intestinal guanylate cyclase: R.C. Wiegand, et al.; BBRC 185, 812 (1992), Abstract;

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