Non-selective antagonist of endothelin-1 with high affinity for both the ETA and ETB receptor subtypes.
Product Details
| Sequence: | Ac-D-Dip-Leu-Asp-Ile-Ile-Trp-OH (D-Dip = D-3,3-Diphenylalanine; Lit. THL 33, 3293 (1992)) |
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| Formula: | C50H65N7O10 |
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| MW: | 924.1 |
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| Quantity: | *Sold as net peptide weight. |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White lyophilized powder. |
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| Solubility: | Soluble in a mixture of 10% acetonitrile and 90% water or in phosphate buffer, pH 7.5. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS
14, 225 (1993), (Review),
Abstract;
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists: A.M. Doherty, et al.; J. Med. Chem.
36, 2585 (1993),
Abstract;
Design of a functional hexapeptide antagonist of endothelin: W.L. Cody, et al.; J. Med. Chem.
35, 3301 (1992),
Abstract;
