Highly potent and selective ETA antagonist.
Product Details
| Sequence: | cyclo(D-Asp-Pro-D-Val-Leu-D-Trp . Na) |
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| Formula: | C31H42N6O7 . Na |
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| MW: | 633.7 |
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| CAS: | 136553-81-6 |
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| Quantity: | *Sold as net peptide weight. |
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| Purity: | ≥96% |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Endothelin: progress in pharmacology and physiology: W.G. Haynes, et al.; TIPS
14, 225 (1993), (Review),
Abstract;
A novel ETA antagonist (BQ-123) inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells: S. Eguchi, et al.; FEBS Lett.
302, 243 (1992),
Abstract;
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor: M. Ihara, et al.; Life Sci.
50, 247 (1992),
Abstract;
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin- A receptor-selective antagonist: R.A. Atkinson & J.T. Pelton; FEBS Lett.
296, 1 (1992),
Abstract;
Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications: K. Ishikawa, et al.; J. Med. Chem.
35, 2139 (1992),
Abstract;
Identification of a domain of ETA receptor required for ligand binding: M. Adachi, et al.; FEBS Lett.
311, 179 (1992),
Abstract;
