Product Details
| Alternative Name: | ET-1 |
| |
| Sequence: | H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11) |
| |
| Formula: | C109H159N25O32S5 |
| |
| MW: | 2492.0 |
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| CAS: | 117399-94-7 |
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| MI: | 14: 3576 |
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| RTECS: | KE9446500 |
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| Quantity: | *Sold as net peptide weight. |
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| Formulation: | Lyophilized. |
| |
| Purity: | ≥98% (HPLC) |
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| Solubility: | 1mg/ml soluble in DMSO or 5% acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
| |
| Use/Stability: | Solution is stable for 1-2 weeks when stored at -20°C. Prepare solution just before use. |
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| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729: R. Huang, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
395, 471 (2022),
Abstract;
Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells: A. Tamalunas, et al.; Life Sci.
308, 120931 (2022),
Abstract;
Lenalidomide and pomalidomide inhibit growth of prostate stromal cells and human prostate smooth muscle contraction: A. Tamalunas, et al.; Life Sci.
281, 119771
(2021),
Abstract;
Endothelin-1 enhanced carotid body chemosensory activity in chronic intermittent hypoxia through PLC, PKC and p38MAPK signaling pathways: J. Li, et al.; Neuropeptides
74, 44 (2019),
Abstract;
Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain.: A. Khodorova, et al.; Physiol. Res.
67, S215 (2018),
Abstract;
Full Text
Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells: J.A. Patel, et al.; Int. J. Mol. Sci.
18, 2372 (2018),
Abstract;
Full Text
Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage: Y.W. Cheng, et al.; Mol. Med. Rep.
18, 5229 (2018),
Abstract;
Mandibular Explant Assay for Investigating Extrinsic Stimuli on Bone and Cartilage Development: J. Jiang, et al.; Bio Protoc.
7, e2641 (2017),
Abstract;
Full Text
Cloning and sequencing of a bovine preproendothelin cDNA: G.J. Price & L. Malone; Nucleic Acids Res.
18, 3658 (1990),
Abstract;
Molecular biology and biochemistry of the endothelins: M. Yanagisawa & T. Masaki; TIPS
10, 374 (1989),
Abstract;
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes: A. Inoue, et al.; PNAS
86, 2863 (1989),
Abstract;
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature
332, 411 (1988),
Abstract;
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett.
231, 440 (1988),
Abstract;
Synthesis and disulfide structure determination of porcine endothelin: an endothelium-derived vasoconstricting peptide: S. Kumagaye, et al.; Int. J. Pept. Prot. Res.
32, 519 (1988),
Abstract;
