Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Details
| Alternative Name: | Cavtratin, AP-Cav, Pen-C1-SD |
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| Sequence: | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH |
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| Formula: | C228H335N61O49S |
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| MW: | 4746.6 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White lyophilized powder. |
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| Solubility: | Soluble in DMSO or acetonitrile:water (50:50). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction: R.K. Batori, et al.; Front. Immunol.
13, 945656 (2022),
Abstract;
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia: D. Passaro, et al.; Cancer Cell
32, 324 (2017),
Abstract;
Full Text
Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells: L. Song, et al.; Blood
109, 1515 (2007),
Abstract;
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS
102, 761 (2005),
Abstract;
Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem.
279, 51630 (2004),
Abstract;
Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell
4, 31 (2003),
Abstract;
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med.
6, 1362 (2000),
Abstract;
Full Text
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane: T. Okamoto, et al.; J. Biol. Chem.
273, 4519 (1998),
Abstract;
Full Text
