Highly specific and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II without affecting cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase IV.
Product Details
| Alternative Name: | AIP |
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| Sequence: | H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH |
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| Formula: | C64H116N22O19 |
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| MW: | 1497.8 |
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| CAS: | 167114-91-2 |
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| Purity: | ≥96% |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels: J. Chemin, et al.; Sci. Rep.
9, 15642 (2019),
Abstract;
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Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia: M.M. Vieira, et al.; Neurobiol. Dis.
89, 223 (2016),
Application(s): Cell culture,
Abstract;
Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia: G. Miletic, et al.; Pain
156, 2514 (2015),
Application(s): Intrathecal injection,
Abstract;
Full Text
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II: A. Ishida, et al.; BBRC
212, 806 (1995),
Abstract;
Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain: A. Ishida & H. Fujisawa; J. Biol. Chem.
270, 2163 (1995),
Abstract;
Full Text
