Competitive inhibitor of indoleamine 2,3-dioxygenase (IDO).
Product Details
| Alternative Name: | 1-MT |
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| Formula: | C12H14N2O2 |
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| MW: | 218.3 |
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| CAS: | 21339-55-9 |
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| RTECS: | YN7135000 |
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| Purity: | ≥95% (Assay) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in acidic or basic aqueous solutions. Soluble in acetic acid 2% (m/v). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells: C.A. Opitz, et al.; PLoS One
6, e19823 (2011),
Abstract;
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Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway: H. J. Ball, et al.; Int. J. Biochem. Cell Biol.
41, 467 (2009),
Abstract;
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses: D.Y. Hou, et al.; Cancer Res.
67, 792 (2007),
Abstract;
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan: R. Metz, et al.; Cancer Res.
67, 7082 (2007),
Abstract;
Prevention of allogeneic fetal rejection by tryptophan catabolism: D.H. Munn, et al.; Science
281, 1191 (1998),
Abstract;
1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase: S.G. Cady & M. Sono; Science
291, 326 (1991),
Abstract;
