Replaces Prod. #: BML-SL200
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Details
| Alternative Name: | S(-)-4-Amino-3-isoxazolidinone |
| |
| Formula: | C3H6N2O2 |
| |
| MW: | 102.1 |
| |
| CAS: | 339-72-0 |
| |
| MI: | 14: 2751 |
| |
| RTECS: | NY2976000 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Unstable in neutral or acidic solutions. |
| |
| Handling: | Hygroscopic. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res.
565, 345 (1991),
Abstract;
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta
1083, 101 (1991),
Abstract;
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res.
510, 158 (1990),
Abstract;
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res.
28, 1478 (1987),
Abstract;
Full Text
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem.
42, 577 (1984),
Abstract;
