L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor. Inhibits proliferation. Enhances neuronal differentiation in progenitor cells.
Product Details
| Alternative Name: | L-Phosphoserine, L-Serine-O-phosphate |
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| Formula: | C3H8NO6P |
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| MW: | 185.1 |
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| CAS: | 407-41-0 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Store tightly sealed. Use fresh solutions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res.
53, 531 (1998),
Abstract;
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review),
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport
4, 1099 (1993),
Abstract;
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem.
56, 1997 (1991),
Abstract;
