Potent inhibitor of endothelial and inducible nitric oxide synthase (eNOS/NOS III and iNOS/NOS II).
Product Details
Alternative Name: | L-NAA . HCl |
|
Formula: | C6H15N5O2 . HCl |
|
MW: | 189.2 . 36.5 |
|
CAS: | 1031799-40-2 |
|
Purity: | ≥97% (TLC)(contains traces of L-ornithine and L-arginine) |
|
Identity: | Determined by IR and 1H-NMR. |
|
Appearance: | White to off-white crystalline powder. |
|
Solubility: | Soluble in water. |
|
Shipping: | Ambient Temperature |
|
Long Term Storage: | +4°C |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group: A.J. Lee, et al.; Chem. Res. Toxicol.
18, 1927 (2005),
Abstract;
Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo: J.L. Vuletich, et al.; Mol. Pharmacol.
62, 110 (2002),
Abstract;
Full Text
Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors: R. Bryk, et al.; Arch. Biochem. Biophys.
369, 243 (1999),
Abstract;
Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine: D.J. Wolff & A. Lubeskie; Arch. Biochem. Biophys.
325, 227 (1996),
Abstract;
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys.
315, 213 (1994),
Abstract;
Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release: H.M. Vargas, et al.; J. Pharmacol. Exp. Ther.
257, 1208 (1991),
Abstract;
Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues: L. Lambert, et al.; Life Sci.
48, 69 (1991),
Abstract;
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG- methylarginine: S.S. Gross, et al.; BBRC
170, 96 (1990),
Abstract;
NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation: J.M. Fukuto, et al.; BBRC
168, 458 (1990),
Abstract;
Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle: L.J. Ignarro, et al.; BBRC
170, 843 (1990),
Abstract;