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N^G-Amino-L-arginine . hydrochloride

NOS inhibitor



ALX-106-014-M005	5 mg	67.00 USD
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Potent inhibitor of endothelial and inducible nitric oxide synthase (eNOS/NOS III and iNOS/NOS II).

Product Details

Alternative Name:	L-NAA . HCl

Formula:	C₆H₁₅N₅O₂. HCl

MW:	189.2 . 36.5

CAS:	1031799-40-2

Purity:	≥97% (TLC)(contains traces of L-ornithine and L-arginine)

Identity:	Determined by IR and ¹H-NMR.

Appearance:	White to off-white crystalline powder.

Solubility:	Soluble in water.

Shipping:	Ambient

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group: A.J. Lee, et al.; Chem. Res. Toxicol. 18, 1927 (2005), Abstract;

Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo: J.L. Vuletich, et al.; Mol. Pharmacol. 62, 110 (2002), Abstract; Full Text

Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors: R. Bryk, et al.; Arch. Biochem. Biophys. 369, 243 (1999), Abstract;

Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine: D.J. Wolff & A. Lubeskie; Arch. Biochem. Biophys. 325, 227 (1996), Abstract;

Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys. 315, 213 (1994), Abstract;

Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release: H.M. Vargas, et al.; J. Pharmacol. Exp. Ther. 257, 1208 (1991), Abstract;

Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues: L. Lambert, et al.; Life Sci. 48, 69 (1991), Abstract;

Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG- methylarginine: S.S. Gross, et al.; BBRC 170, 96 (1990), Abstract;

NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation: J.M. Fukuto, et al.; BBRC 168, 458 (1990), Abstract;

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle: L.J. Ignarro, et al.; BBRC 170, 843 (1990), Abstract;