Intermediate in the biosynthesis of nitric oxide from L-arginine by nitric oxide synthases (NOS). Inhibitor of arginases.
Product Details
| Alternative Name: | L-HOArg . AcOH |
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| Formula: | C6H14N4O3 . CH3COOH |
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| MW: | 190.2 . 60.1 |
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| CAS: | 53598-01-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms: G.M. Buga, et al.; Am. J. Physiol.
275, R1256 (1998),
Abstract;
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Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production: G.M. Buga, et al.; Am. J. Physiol.
271, H1988 (1996),
Abstract;
Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis: M. Hecker, et al.; FEBS Lett.
359, 251 (1995),
Abstract;
Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity: C.A. Schott, et al.; FEBS Lett.
341, 203 (1994),
Abstract;
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys.
315, 213 (1994),
Abstract;
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase: F. Daghigh, et al.; BBRC
202, 174 (1994),
Abstract;
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase: J.-L. Boucher, et al.; BBRC
203, 1614 (1994),
Abstract;
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry
31, 6822 (1992), [Synthesis],
Abstract;
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem.
266, 6259 (1991),
Abstract;
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N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery: G.C. Wallace, et al.; BBRC
176, 528 (1991),
Abstract;
Nitric oxide and another potent vasodilator are formed from NG-hydroxy- L-arginine by cultured endothelial cells: A. Zembowicz, et al.; PNAS
88, 11172 (1991),
Abstract;
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett.
294, 221 (1991),
Abstract;
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine: G.C. Wallace & J.M. Fukuto; J. Med. Chem.
34, 1746 (1991), [Synthesis],
Abstract;
Synthesis of the putative L-arginine metabolite L-NG-hydroxyarginine: P.L. Feldman; Tetrahedron Lett. 32, 875 (1991),
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate: M.A. Marletta, et al.; Biochemistry
27, 8706 (1988),
Abstract;
