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Synapsin II polyclonal antibody

 
ADI-VAS-SV061-E 100 µg 268.00 USD
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Product Specification

Alternative Name:SYN2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of rat Synapsin II. The sequence is completely conserved in mouse.
 
UniProt ID:Q63537
 
Gene/Protein Identifier:C30411 (PIR)
 
Source:Purified from rabbit serum.
 
Species reactivity:Mouse, Rat
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~74kDa (synapsin Iia) and ~54kDa (synapsin Iib) by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Synapsin I, II and III belong to a family of neuron-specific phosphoproteins which maintain a reserve pool of vesicles in the vicinity of the active zone by tethering synaptic vesicles to each other and to an Actin-based cytoskeleton meshwork. They have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L: E. Coccia, et al.; Cell Death Dis. 11, 82 (2020), Abstract; Full Text

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