Product Specification
| Alternative Name: | STX1A |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to a portion of rat Syntaxin 1A. |
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| UniProt ID: | P32851 |
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| GenBank ID: | D12519 |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Mouse, Rat
Bovine
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| Applications: | IHC (PS), IP, WB
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| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~35-36kDa by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles. |
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| Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human brain, cortex tissue stained with Syntaxin 1A, pAb at 10µg/ml.
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Product Literature References
Disrupted dynamics of F-actin and insulin granule fusion in INS-1832/13 Beta-cells exposed to glucotoxicity: Partial restoration by glucagon-like peptide 1: A. Quinault, et al.; Biochim. Biophys. Acta
1862, 1401 (2016),
Application(s): Western blotting,
Abstract;
Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex: J.E. Pessin, et al. ; Mol. Endocrinol.
17, 732 (2003),
Application(s): WB using rat samples,
Abstract;
Identification of SNARE and cell trafficking regulatory proteins in the salivary glands of the lone star tick, Amblyomma americanum (L.): J.R. Sauer, et al. ; Insect Biochem. Mol. Biol.
32, 1711 (2002),
Application(s): WB using insect samples,
Abstract;
Synaptotagmin I is a molecular target for lead: J. Pevsner, et al. ; J. Neurochem.
76, 1724 (2001),
Application(s): IP using rat samples,
Abstract;
G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and G beta gamma: G.W. Zamponi, et al. ; J. Biol. Chem.
275, 6388 (2000),
Application(s): WB using rat samples,
Abstract;
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