Syntaxin 6 monoclonal antibody (3D10)



ADI-VAM-SV025-D	50 µg	247.00 USD

ADI-VAM-SV025-F	200 µg	487.00 USD
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Product Details

Alternative Name:	STX6

Clone:	3D10

Host:	Mouse

Isotype:	IgG1

Immunogen:	Recombinant rat Syntaxin 6.

UniProt ID:	Q63635

Source:	Purified from mouse ascites.

Species reactivity:	Human, Mouse, Rat Hamster

Applications:	IP, WB

Recommended Dilutions/Conditions:	Immunoprecipitation (12µg/ml) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~35kDa by Western blot.

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles.

Regulatory Status:	RUO - Research Use Only

Syntaxin 6 monoclonal antibody (3D10) Western blot

Western blot analysis of Syntaxin 6: Lane 1: CHO-K1, Lane 2: Mouse Brain, Lane 3: Rat Brain.

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Product Literature References

Post-Golgi anterograde transport requires GARP-dependent endosome to TGN retrograde transport: T. Hirata, et al.; Mol. Biol. Cell 26, 3071 (2015), Application(s): Western Blot, Abstract; Full Text

Immunoglobulin mu heavy chains do not mediate tyrosine phosphorylation of Ig alpha from the ER-cis-Golgi: H.M. Jack, et al. ; J. Immunol. 171, 3091 (2003), Application(s): ICC using mouse samples, Abstract;

Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest: V. Deretic, et al. ; PNAS 100, 5437 (2003), Application(s): WB using mouse samples, Abstract;

Complex N-linked glycosylated nicastrin associates with active gamma -secretase and undergoes tight cellular regulation: D.J. Selkoe, et al. ; J. Biol. Chem. 277, 35113 (2002), Application(s): WB using human samples, Abstract;

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