Product Details
| Alternative Name: | GOSR2, golgi SNAP receptor complex member |
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| Clone: | 4HAD6 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant rat Membrin protein with a His tag. |
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| UniProt ID: | O35165 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Human, Rat
Chicken, Dog, Hamster, Monkey, Porcine, Rabbit
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| Applications: | ICC, IHC (PS), WB
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| Application Notes: | Detects a band of ~27kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 0.1MM PMSF and 50% glycerol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Membrin, also known as GS27 (Golgi SNARE of 27K), is an integral membrane protein present on the surface of the Golgi apparatus. GS27 is a member of a protein complex that consists of cis-Golgi vesicle receptor syntaxin 5 and GS28, v-SNARE rbet1 and Rsec22, and Rsly1. These complexes are postulated to direct the fusion of ER-derived vesicles with vesicular tubular cluster (VTC), and the fusion of VTCs to form cis-Golgi compartment. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of VAM-PT046: Lane 1: MW marker, Lane 2: HeLa, Lane 3: PC-12, Lane 4: RK13, Lane 5: Vero.
Immunohistochemistry analysis of human pancreas tissue stained with Membrin, mAb (4HAD6) at 20µg/ml.
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Product Literature References
Expression of the Heterotrimeric GP2/GP3/GP4 Spike of an Arterivirus in Mammalian Cells: A.K. Matczuk, et al.; Viruses
14, 749 (2022),
Abstract;
Myopathy can be a key phenotype of membrin (GOSR2) deficiency: M.G. Stemmerik, et al.; Hum. Mutat.
42, 1101 (2021),
Abstract;
Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery: V.V. Lupashin, et al. ; J. Biol. Chem.
276, 22810 (2001),
Application(s): ICC using human samples,
Abstract;
