| Alternative Name: | Synapse-associated protein 102, Disks large homolog 3 |
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| Clone: | 7D3, mAb 119 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant rat SAP102 (N-terminal fragment). |
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| UniProt ID: | Q62936 |
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| GenBank ID: | U50147 |
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| Source: | Purified from mouse ascites. |
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| Species reactivity: | Mouse, Rat
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| Applications: | IHC, IP, WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~102kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Synapse-associated proteins SAP97 and SAP102 display extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminals. In addition to the CNS, SAP97 is also detected at the basal lateral membrane between a variety of epithelial cells. SAP102 associates with NMDA receptors through the C-terminal NR2B subunit of the receptor. The N-terminal SAP97 PDZ domain mediates its interaction with the synaptic ras-GTPase activating protein SynGAP. |
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| Regulatory Status: | RUO - Research Use Only |
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