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PSD-95 monoclonal antibody (6G6-1C9)

ADI-VAM-PS002-E 100 µg 374.00 USD
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Product Details

Alternative Name:Postsynaptic density protein 95, Disks large homolog 4, Synapse-associated protein 90, SAP90
Immunogen:Recombinant rat PSD-95.
UniProt ID:Q62108
Source:Purified from ascites.
Species reactivity:Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Immunocytochemistry (12.5µg/ml)
Western Blot (1:250, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~100kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively.
Regulatory Status:RUO - Research Use Only
PSD-95 monoclonal antibody (6G6-1C9) Western blot
Western blot analysis of bovine brain tissue extract, probed with PSD-95 mAb (6G6-1C9).
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PSD-95 monoclonal antibody (6G6-1C9) Western blot

Product Literature References

Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology: M. Kaneda, et al.; Sci. Rep. 8, 727 (2018), Abstract; Full Text
Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons: T. Imamura, et al. ; Eur. J. Neurosci. 16, 1313 (2002), Application(s): ICC using rat samples, Abstract;

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