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LAMP2 monoclonal antibody (GL2A7)

ADI-VAM-EN003-D 50 µl 254.00 USD
ADI-VAM-EN003-F 200 µl 530.00 USD
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Product Details

Alternative Name:Lysosomal-associated membrane protein 2
Immunogen:Mouse liver lysosomal membrane preparation.
UniProt ID:P17047
GenBank ID:J05287
Source:Purified from ascites.
Species reactivity:Mouse
Applications:ICC, IP, WB
Recommended Dilutions/Conditions:Immunocytochemistry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. Rat Ascites.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Hsp47-dependent and -independent intracellular trafficking of type I collagen in corneal endothelial cells: E.P. Kay, et al. ; Mol. Vis. 5, 17 (1999), Application(s): ICC using rabbit samples, Abstract;
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells: G.M. Bokoch, et al. ; J. Cell Biol. 138, 1265 (1997), Application(s): ICC using mouse samples, Abstract;
Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells: B.L. Granger, et al.; J. Biol. Chem. 265, 12036 (1990), Application(s): ICC, IP, WB using mouse samples, Abstract;

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