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HSC70/HSP73 (ATPase fragment) (bovine), (recombinant)

ADI-SPP-752-D 50 µg 222.00 USD
ADI-SPP-752-F 200 µg 534.00 USD
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Product Specification

Alternative Name:Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, HSPA8
Source:Produced in E. coli.
UniProt ID:P19120
Formulation:Liquid. In 10mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride, 3mM magnesium chloride, and 1mM DTT.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Applications:Activity assay
Application Notes:ATPase activity assay (positive).
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
Regulatory Status:RUO - Research Use Only

Product Literature References

Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove: K.M. Rohrer, et al.; Immunology 142, 237 (2014), Abstract; Full Text

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