Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

HSP40/Hdj2 (human), (recombinant)

ADI-SPP-405-D 50 µg 263.00 USD
ADI-SPP-405-F 200 µg 631.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:Heat shock protein 40, DnaJ protein homolog 2
Recommended Dilutions/Conditions:Western Blot (100ng, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Source:Produced in E. coli.
UniProt ID:P31689
Formulation:Liquid. In TBS containing 1mM DTT.
Purity:≥90% (SDS-PAGE; Western blot)
Purity Detail:Purified by multi-step chromatography.
Application Notes:Western blot control.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Hdj2 is an approximately 40 kDa member of the heat shock protein (HSP40) family, a eukaryotic homolog of the E. coli DnaJ protein. Eukaryotic DnaJ-like proteins share structural domain conservation with DnaJ, namely: 1) an N-terminal ~70 amino acid J domain, 2) a glycine- and phenylalanine-rich domain, 3) a cysteine-rich zinc finger domain, and 4) a poorly conserved C-terminal domain. The human constitutive Hdj2 protein shares full domain conservation with DnaJ, as opposed to the human inducible Hdj1 which lacks the zinc-finger domain. The HSP40 J domain regulates its interaction with HSP70 (E. coli DnaK), increasing HSP70 ATPase activity and in turn enhancing substrate binding by the HSP70 chaperone. HSP40 co-chaperones are involved in nearly all aspects of protein synthesis and secretion because of their importance in HSP70 function, and they are also thought to have an intrinsic ability to bind and fold some misfolded proteins. Hdj2 has been specifically shown to interact with Hsc70, the constitutive form of HSP70, in the biogenesis of the cystic fibrosis transmembrane conductance regulator (CFTR), mutations of which are known to cause inherited cystic fibrosis.
Regulatory Status:RUO - Research Use Only
HSP40/Hdj2 (human), (recombinant) SDS-PAGE
SDS-PAGE analysis of HSP40/Hdj2 (human), (recombinant) (Prod. No. ADI-SPP-405): Lane 1: MWM, Lane 2: 0.5μg, Lane 3: 1μg, Lane 4: 2μg, Lane 5: 5μg.
HSP40/Hdj2 (human), (recombinant) Western blot
Western Blot analysis: Lane 1: MW marker, Lane 2: Hdj2 probed with anti-Hdj2 mAb.
Please mouse over
HSP40/Hdj2 (human), (recombinant) SDS-PAGE HSP40/Hdj2 (human), (recombinant) Western blot

Product Literature References

Anti-Inflammatory Peptide Regulates the Supply of Heat Shock Protein 70 Monomers: Implications for Aging and Age-Related Disease: T. Cunningham, et al.; Rejuvenation Res. 18, 136 (2015), Abstract; Full Text

Related Products

Goat anti-mouse IgG, polyclonal antibody (AP conjugate) 

ELISA, WB | Print as PDF
ADI-SAB-101-J 1 ml 175.00 USD
Do you need bulk/larger quantities?

HeLa, (cell lysate) 

Human, WB | Print as PDF
ADI-LYC-HL100-F 200 µg 141.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
HSP40 Recombinant protein
By catalog section:


Technical Service
Customer Service