| ADI-SPA-842-D | 50 µg | 249.00 USD |  |
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| ADI-SPA-842-F | 200 µg | 526.00 USD | |
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| Alternative Name: | HSP86, Heat shock protein 90β |
| Clone: | K3705 |
| Host: | Mouse |
| Isotype: | IgM |
| Immunogen: | Recombinant human HSP90β. |
| UniProt ID: | P08238 |
| Source: | Purified from hybridoma tissue culture supernatant. |
| Species reactivity: | Human, Mouse, Rat Bovine, Chicken, Dog, Guinea pig, Hamster, Porcine, Sheep |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:50) Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~90kDa by Western blot. |
| Purity Detail: | Ammonium sulfate precipitation purified. |
| Formulation: | Liquid. In saline, pH 6.9, containing 0.1% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents. |
| Regulatory Status: | RUO - Research Use Only |
Goat anti-mouse IgG, polyclonal antibody (AP conjugate) |
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| ELISA, WB | Print as PDF | ||||||
| ADI-SAB-101-J | 1 ml | 170.00 USD | |
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HeLa, (cell lysate) |
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| Human, WB | Print as PDF | ||||||
| ADI-LYC-HL100-F | 200 µg | 137.00 USD | |
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