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United States 

HSP70/HSP72 monoclonal antibody (C92F3A-5) (FITC conjugate)

ADI-SPA-810FI-D 50 µg 289.00 USD
ADI-SPA-810FI-F 200 µg 553.00 USD
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Product Details

Alternative Name:Hsp70, HspA1A, Heat shock protein 70, HspA1B, Hsp72
Immunogen:Native human Hsp70.
GenBank ID:M11717
Gene/Protein Identifier:NP_005336.3 (RefSeq), NM_005345 (RefSeq), 3303 (Entrez GeneID), 140550 (OMIM)
Source:Purified from ascites.
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Drosophila, Fish, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep
Applications:Flow Cytometry
Recommended Dilutions/Conditions:Flow Cytometry (1:20)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~70kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Handling:Do not freeze. Protect from light.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
Regulatory Status:RUO - Research Use Only
HSP70/HSP72 monoclonal antibody (C92F3A-5) (FITC conjugate) Flow Cytometry
Flow cytometry analysis of 106 Jurkat cells stained using HSP70/HSP72, mAb (C92F3A-5) (FITC conjugate) at a concentration of 50µg/ml.
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HSP70/HSP72 monoclonal antibody (C92F3A-5) (FITC conjugate) Flow Cytometry

Product Literature References

Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme: R.V. Vince, et al.; Cell Stress Chaperones 25, 73 (2020), Abstract; Full Text
HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus: R.R. Porto, et al.; Neuroscience 375, 108 (2018), Abstract;
Cross acclimation between heat and hypoxia: heat acclimation improves cellular tolerance and exercise performance in acute normobaric hypoxia: B.J. Lee, et al.; Front. Physiol. 7, 78 (2016), Application(s): Flow cytometry using monocytes, Abstract; Full Text
Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation: B.J. Lee, et al.; Biomed. Res. Int. 2015, 849809 (2015), Application(s): Flow cytometry using monocytes, Abstract; Full Text
Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90a in Severe Sepsis and SIRS: K. Vardas, et al.; BioMed Research International 2014, 803561 (2014), Application(s): intracellular staining in flow cytometry of human blood, Abstract; Full Text

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