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HSP27 monoclonal antibody (G3.1) (FITC conjugate)

ADI-SPA-800FI-D 50 µg 296.00 USD
ADI-SPA-800FI-F 200 µg 639.00 USD
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Product Details

Alternative Name:HspB1, Heat shock protein 27
Immunogen:Native human Hsp27.
UniProt ID:P04792
GenBank ID:L39370
Source:Purified from mouse ascites.
Species reactivity:Human, Mouse, Rat
Bovine, Fish, Monkey
Applications:Flow Cytometry
Recommended Dilutions/Conditions:Flow Cytometry (10-20µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles. Protect from light.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.
Regulatory Status:RUO - Research Use Only
HSP27 monoclonal antibody (G3.1) (FITC conjugate) Flow Cytometry
Flow cytometry analysis of 106 Jurkat cells stained using HSP27 mAb (G3.1), Fluorescein Conjugate at a concentration of 10 and 20µg/ml.
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HSP27 monoclonal antibody (G3.1) (FITC conjugate) Flow Cytometry

Product Literature References

The small heat shock protein 27 is a key regulator of CD8+ CD57+ lymphocyte survival: K. Wood, et al.; J. Immunol. 15, 184 (2010), Application(s): Analysis human lymphocytes using Flow Cytometry, Abstract; Full Text

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