Product Details
| Alternative Name: | PDIA3, ERp60, ERp61, GRP57, Grp58 |
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| Clone: | MaP.Erp57 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human ERp57. |
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| UniProt ID: | P30101 |
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| GenBank ID: | U42068 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Human
Dog, Hamster, Monkey, Porcine
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| Applications: | IHC, WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~58kDa by Western blot. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | ERp57 (also known as Grp58), a member of the Thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of ERp57, mAb (MaP.Erp57) (Prod. no. ADI-SPA-725) : Lane 1: HeLa Cell Lysate, Lane 2: HeLa Cell Lysate (Heat Shocked), Lane 3: MDCK, Lane 4: MDCK (Heat Shocked), Lane 5: CHO-K1, Lane 6: ESK-4, Lane 7: Vero.
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Product Literature References
Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE: L.F. Zacchi, et al.; Dis. Model. Mech.
10, 1129 (2017),
Abstract;
Full Text
Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells: G.M. Lee, et al. ; Biotechnol. Prog.
19, 179 (2003),
Application(s): WB using human samples,
Abstract;
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors: D.G. Beer, et al. ; Clin. Cancer Res.
8, 2298 (2002),
Application(s): IHC, WB using human samples,
Abstract;
Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading: F. Momburg, et al. ; J. Immunol.
168, 1950 (2002),
Application(s): WB using human samples,
Abstract;
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