Product Details
| Alternative Name: | Prostaglandin E synthase 3, HSP90 Co-chaperone |
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| Host: | Rabbit |
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| Immunogen: | Recombinant human p23. |
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| UniProt ID: | Q15185 |
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| Source: | Whole rabbit serum. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~23kDa by Western blot. |
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| Purity Detail: | Antiserum. |
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| Formulation: | Serum. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | p23 is a ubiquitous, highly conserved co-chaperone for Hsp90 that participates in the folding of a number of cell regulatory proteins including progesterone and glucocorticoid receptors, HSF1, and telomerase. p23 is thought to modulate Hsp90 activity in the last stages of the chaperoning pathway by binding and stabilizing Hsp90 in its ATP-bound state. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of p23: Lane 1: MW, Lane 2: p23 (Prod. No. ADI-SPP-670), Lane 3: HeLa (Heat Shocked), Lane 4: mouse testes, and Lane 5: rat testes probed with p23, pAb (Prod. No. ADI-SPA-670).
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Product Literature References
A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand: S.J. Backe, et al.; Cell Rep.
40, 111039 (2022),
Abstract;
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma: M. Heider, et al.; Mol. Cell
81, 1170 (2021),
Abstract;
Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE: K. Saito, et al.; Eur. J. Immunol.
45, 2028 (2015),
Abstract;
Full Text
Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90: C. Wang, et al.; Nat. Immunol.
14, 72 (2013),
Application(s): WB using MEF extracts,
Abstract;
Full Text
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