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Calcineurin A polyclonal antibody

ADI-SPA-610-D 50 µg 199.00 USD
ADI-SPA-610-F 200 µg 457.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to human calcineurin A.
UniProt ID:P16298
GenBank ID:M29550
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep
Applications:IP, WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~61kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Calcineurin is a Ca2+/Calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit and a myristylated regulatory B subunit that binds calcium. Calcineurin, which is the target of immunosuppressant drugs such as cyclosporin A and FK506, controls the translocation of Nuclear factors of activated T-cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T-cells.
Regulatory Status:RUO - Research Use Only
Calcineurin A polyclonal antibody Western blot
Western blot analysis of ADI-SPA-610: Lane 1: Rat Brain Lysate, Lane 2: Mouse Brain Lysate.
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Calcineurin A polyclonal antibody Western blot

Product Literature References

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation: A.B. Bachman, et al.; Nat. Commun. 9, 265 (2018), Application(s): Immunoprecipitation, Abstract; Full Text
Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth: R.N. Michel, et al. ; J. Cell Biol. 151, 663 (2000), Application(s): WB using mouse samples, Abstract;

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Serine/threonine-protein phosphatase
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Serine/threonine-protein phosphatase Polyclonal antibody
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