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[pSer45]αB-Crystallin polyclonal antibody

ADI-SPA-226-D 50 µg 269.00 USD
ADI-SPA-226-F 200 µg 569.00 USD
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Product Details

Alternative Name:CRYAB, HSPB5
Immunogen:Synthetic peptide corresponding to a portion of human αB-crystallin phosphorylated at Ser45.
UniProt ID:P02511
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Scallop, Xenopus
Applications:IP, WB
Recommended Dilutions/Conditions:Western Blot (1:500, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~22kDa by Western blot.
Purity Detail:Affinity purified.
Formulation:Liquid. In 0.1M sodium phosphate buffer, pH 7.0, containing 1.5% BSA and 0.1% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
Regulatory Status:RUO - Research Use Only
[pSer45]αB-Crystallin polyclonal antibody Western blot
Western blot analysis of Crystallin alpha-B (pSer45): Lane 1: MW marker, Lane 2: alpha-B1 Crystallin Protein (phospho), Lane 3: alpha-B2 Crystallin Protein (non-phospho)
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[pSer45]αB-Crystallin polyclonal antibody Western blot

Product Literature References

Phosphorylation of the chaperone-like HspB5 rescues trafficking and function of F508del-CFTR: F. Degrugillier, et al.; Int. J. Mol. Sci. 21, E4844 (2020), Application(s): Western-blot using CFBE cells, Abstract;
AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system: E.M.F. Lim, et al.; Neurobiol. Aging 53, 318 (2017), Application(s): Western-blot using mouse sciatic nerve lysates, Abstract;
Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis: G. Fung, et al.; Oncotarget 8, 74767 (2017), Application(s): Western-blot using HL-1 cells and mouse cardiac tissue, Abstract; Full Text
Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats: B. Bartelt-Kirbach, et al.; Cell Stress Chaperones 22, 653 (2017), Abstract; Full Text
Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis: S.W. Lee, et al.; PLoS One 11, e0166450 (2016), Abstract; Full Text

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