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GPCR obesity, Ab sample pack

ADI-PAK-120 6x25 µg 626.00 USD
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Antibody sample packs are designed to be cost effective and help you choose which of our many antibodies might work best for your particular sample type or application. This antibody sample pack includes a set of related GPCR polyclonal antibodies for obesity research.

Product Details

Applications:ELISA, IHC, WB
Application Notes:Application varies by product.
Contents:Contains 25µg each of the following Abs:
Cannabinoid receptor CB1, pAb (Prod. No. ADI-905-708)
Cannabinoid receptor CB2, pAb (Prod. No. ADI-905-749)
Cholecystokinin receptor CCK1, pAb (Prod. No. ADI-905-788)
Ghrelin receptor GHS-R, pAb (Prod. No. ADI-905-792)
Melanocortin receptor MC4, pAb (Prod. No. ADI-905-795)
Neuropeptide Y receptor Y1, pAb (Prod. No. ADI-905-798)
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The GPCR cannabinoid receptors, CB1 and CB2, are named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). CB1 and CB2 signals regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.Cholecystokinin (CCK) is a gastrointestinal peptide hormone released by enteroendocrine cells (I cells) of the small intestine and from specific neurons in the myenteric plexus and brain. The GPCR CCK1 receptor displays preferential binding to sulfated CCK, whereas the GPCR CCK2 receptor binds both gastrin and CCK with equal affinity. Ghrelin is a multifunctional peptide hormone secreted from the anterior pituitary known to affect many physiological processes including the release of growth hormone, appetite regulation, gastric acid secretion, gastrointestinal motility, and blood pressure regulation. The GPCR ghrelin receptor (GHS-R) is expressed in the hippocampus, pituitary, and hypothalamus, as well as in peripheral tissues including the heart, lung, liver, kidney, pancreas, intestines, and immune cells.Melanocortin receptors serve as the principle receptors for the pro-opiomelanocortin (POMC) family of peptide agonists, as well as agouti and agouti-related protein (AGRP) inverse agonists. POMC derived peptides include adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (alpha, beta and gamma-MSH), and beta-endorphin. Five known melanocortin receptors (MC1-MC5) display distinct and relatively localized expression patterns that contribute to their physiological activity. Neuropeptide Y (NPY) and the closely related peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino acid, tyrosine-rich peptides with amidated C-terminal ends that are known to regulate gastrointestinal and central nervous system functions including food intake and the inhibition of anxiety. Four functional NPY receptors (Y1/Y2/Y4/Y5) have been identified to date, with a fifth (y6) being a non-functional receptor in primates that is absent from the rat genome. Y1 receptor deficient mice display a variety of physical and behavioral phenotypes including obesity, hyperinsulinemia, and increased territorial behavior.
Regulatory Status:RUO - Research Use Only

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