Product Details
Alternative Name: | BLVR |
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Host: | Rabbit |
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Immunogen: | Recombinant rat Biliverdin Reductase. |
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UniProt ID: | P46844 |
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GenBank ID: | M81681 |
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Source: | Purified from rabbit serum. |
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Species reactivity: | Mouse, Rat E. coli
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Applications: | IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (1:100) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects bands of ~33kDa by Western blot. |
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Purity Detail: | Ammonium sulfate precipitation purified. |
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Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | The phosphoprotein BVR (Biliverdin Reductase) is an oxireductase which catalyzes the reduction of the gamma-meso bridge of Biliverdin to Bilirubin. BVR is unique among all enzymes characterized to date because BVR has dual pH/dual cofactor requirements. The reductase is highly conserved in its primary structure and molecular properties and uses NADH in the acidic range (peak activity at pH~6.7), whereas NADPH is utilized in the basic range (peak activity at pH ~8.7). |
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Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of Biliverdin Reductase, pAb (Prod. No. ADI-OSA-450): Lane 1: MW Marker, Lane 2: Biliverdin Reductase Protein (rat) (recombinant) (Prod. No. ADI-OSP-450), Lane 3: Rat-2 Cell Lysate, Lane 4: 3T3 Cell Lysate (Prod. No. ADI-LYC-3T100), Lane 5: PC-12 Cell Lysate (Prod. No. ADI-LYC-PC100), Lane 6: HO-1 Protein (rat) (recombinant) (Prod. No. ADI-SPP-730)
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Product Literature References
Induction of BVR-A Expression by Korean Red Ginseng in Murine Hippocampal Astrocytes: Role of Bilirubin in Mitochondrial Function via the LKB1-SIRT1-ERRα Axis: S. Moon, et al.; Antioxidants
11, 1742 (2022),
Abstract;
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