Drebrin monoclonal antibody (M2F6)



ADI-NBA-110-E	100 µg	376.00 USD
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Product Details

Alternative Name:	DBN

Clone:	M2F6

Host:	Mouse

Isotype:	IgG1

Immunogen:	Chicken Drebrin E.

UniProt ID:	P18302

Species reactivity:	Human, Mouse, Rat Bovine, Cat, Chicken, Rabbit

Applications:	ICC, IHC, IP, WB

Recommended Dilutions/Conditions:	Immunohistochemistry (10µg/ml) Western Blot (1µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~110kDa by Western blot.

Purity Detail:	Protein A affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Drebrins are actin-binding proteins that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single Drebrin gene in the chicken brain. It has been suggested that Drebrin is one of the intracellular regulators of the neuronal morphogenesis.

Regulatory Status:	RUO - Research Use Only

Drebrin monoclonal antibody (M2F6) Western blot

Western blot analysis of Drebrin expression in mouse brain (1) NIH/3T3 (2), Jurkat (3), HeLa (4), and PC12 (5) using Drebrin mAb (M2F6).

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Product Literature References

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease: L. Trujillo-Estrada, et al.; Neurotherapeutics 18, 2468 (2021), Abstract;

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans: P. Kreis, et al.; Nat. Commun. 10, 486 (2019), Abstract; Full Text

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability: S. Kaniyappan, et al.; Alzheimers Dement. 13, 1270 (2017), Abstract;

Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One 10, e0125119 (2015), Application(s): Immunostaining, Abstract; Full Text

Changes of drebrin expression in the visual cortex of the cat during development: K. Obata, et al. ; Neurosci. Res. 13, 33 (1992), Application(s): WB, IHC using feline samples, Abstract;

Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution: K. Obata, et al. ; Brain Res. 394, 233 (1986), Application(s): IHC, WB using chicken samples, Abstract;

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