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Drebrin monoclonal antibody (M2F6)

ADI-NBA-110-E 100 µg 376.00 USD
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Product Details

Alternative Name:DBN
Immunogen:Chicken Drebrin E.
UniProt ID:P18302
Species reactivity:Human, Mouse, Rat
Bovine, Cat, Chicken, Rabbit
Applications:ICC, IHC, IP, WB
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~110kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Drebrins are actin-binding proteins that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single Drebrin gene in the chicken brain. It has been suggested that Drebrin is one of the intracellular regulators of the neuronal morphogenesis.
Regulatory Status:RUO - Research Use Only
Drebrin monoclonal antibody (M2F6) Western blot
Western blot analysis of Drebrin expression in mouse brain (1) NIH/3T3 (2), Jurkat (3), HeLa (4), and PC12 (5) using Drebrin mAb (M2F6).
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Drebrin monoclonal antibody (M2F6) Western blot

Product Literature References

SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease: L. Trujillo-Estrada, et al.; Neurotherapeutics 18, 2468 (2021), Abstract;
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans: P. Kreis, et al.; Nat. Commun. 10, 486 (2019), Abstract; Full Text
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability: S. Kaniyappan, et al.; Alzheimers Dement. 13, 1270 (2017), Abstract;
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One 10, e0125119 (2015), Application(s): Immunostaining, Abstract; Full Text
Changes of drebrin expression in the visual cortex of the cat during development: K. Obata, et al. ; Neurosci. Res. 13, 33 (1992), Application(s): WB, IHC using feline samples, Abstract;
Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution: K. Obata, et al. ; Brain Res. 394, 233 (1986), Application(s): IHC, WB using chicken samples, Abstract;

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