| ADI-NBA-104-E | 100 µg | 368.00 USD |  |
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| Clone: | 2C8 |
| Host: | Mouse |
| Isotype: | IgG2b |
| Immunogen: | Synthetic peptide corresponding to aa 1-16 of human Amyloid β. |
| UniProt ID: | P05067 |
| Species reactivity: | Human |
| Crossreactivity: | Weakly cross-reacts with mouse β-amyloid. |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (10µg/ml) Western Blot (0.5-1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Predicted MW of ~4kDa. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Beta-amyloid/A-beta is the major protein component of neurofibrillary tangles and senile plaques, major neruopthological hallmarks of Alzheimer's disease (AD). Abeta occurs in two predominant forms with different COOH-termini, A-beta 40 and A-beta 42. A-beta is generated by proteolytic cleavage of the amyloid precursor protein (APP) at two sites by distinct secretases, the beta-site secretase BACE, and the multi-subunit gamma-secretase composed of presenilin, nicastrin, Aph-1, and Pen-2. |
| Regulatory Status: | RUO - Research Use Only |
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