Product Details
| Clone: | 9A6 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human GAD65. |
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| UniProt ID: | Q05329 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 1-10µg/ml)
Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects bands of ~65kDa and ~67kDa, (corresponding to GAD65 and GAD67, respectively) by Western blot. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | GAD, glutamic acid decarboxylase, is an integral membrane protein that catalyzes the formation of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter. The biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system and modulation of cell proliferation, protein synthesis, and metabolism. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of mouse (1) and rat (2) brain extracts, probed with GAD65/67, mAb (9A6).
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Product Literature References
Effects of lateral olfactory tract stimulation on Fos immunoreactivity in vasopressin neurones of the rat piriform cortex: C. Tsuji, et al.; J. Neuroendocrinol.
29, (2017),
Application(s): IHC on free floating rat tissue sections,
Abstract;
Vasopressin casts light on the suprachiasmatic nucleus: T. Tsuji, et al.; J. Physiol.
595, 3497 (2017),
Application(s): IHC in rat retina and suprachiasmatic nucleus,
Abstract;
Full Text
Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated: D.H. Kim, et al.; Front. Neural Circuits
5, 5 (2011),
Abstract;
Attractin/mahogany protein expression in the rodent central nervous system: K. Nakadate, et al.; J. Comp. Neurol.
508, 94 (2008),
Abstract;
An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease: D.A. Pearce, et al. ; Hum. Mol. Genet.
11, 1421 (2002),
Application(s): IHC, WB using human & mouse samples,
Abstract;
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